People » Gang Chen


My research interest is to design and build nanomaterials rationally from the viewpoint of material chemistry. My previous work include exploring new synthetic strategy for nanomaterials with demand shape and functionality; revealing the mechanism of nanoparticle 1D array formation in colloidal solution and sorting the nanoclusters by density gradient centrifugation; realizing scalable production of DNA origami through enzymatic reactions and utilizing these DNA nanostructures as effective carriers for nanomedicine application; creating complex molecular topologies by configuring DNA four-way junctions.

Currently, our research projects are targeting the miniaturization of the microelectromechanical system (MEMS) to nanoscale, which is promising to measure small displacement and force at the molecular scale. Specifically, we want to improve the structural complexity of nanomaterials through rational design in nano-synthesis; realize the programmable self-assembly of nanoparticles with appropriate orientation via surface pattering of nanoparticles with DNA; combine the routine materials with nanoparticles to enhance their inherent properties or create new properties.

  1. Site-Specific Functionalization of Nanoparticles for Programmable Self-Assembly, Chen, G.; Liu, D.; Rees, H. C.; Weizmann, Y., submitted.
  2. Synthesizing Topological Structures Containing RNA, Liu, D.; Shao, Y.; Chen, G.; Tse-Dinh, Y. –C.; Piccirilli, J. A.; Weizmann, Y., submitted.
  3. Creating Complex Molecular Topologies by Configuring DNA Four-Way Junctions, Liu, D.; Chen, G.; Akhter U.; Cronin, T. M.; Weizmann, Y., Nature Chemistry, 2016, doi: 10.1038/nchem.2564.
  4. Bipyramid-Templated Synthesis of Monodisperse Anisotropic Gold Nanocrystals, Lee, J.-H.; Gibson, K. J.; Chen, G.; Weizmann, Y., Nat. Commun. 2015, 6, 7571.
  5. Enzymatic Synthesis of Periodic DNA Nanoribbons for Intracellular pH Sensing and Gene Silencing, Chen, G.; Liu, D.; He, C. B.; Gannett, T. R.; Lin, W. B.; Weizmann, Y., J. Am. Chem.Soc.2015, 137 (11), 3844-3851. Spotlights and Front Cover.
  6. Chiral Transformation: from Single Nanowire to Double Helix, Wang, Y.; Wang, Q. X.; Sun, H.; Zhang, W.Q.; Chen, G.; Wang, Y. W.; Shen, X. S.; Han, Y.; Lu, X. M.; Chen, H. Y., J. Am. Chem. Soc. 2011, 133 (50), 20060-20063.
  7. Toroidal Micelles of Polystyrene-block-Poly(acrylic acid), Liu, C.; Chen, G.; Sun, H.; Xu, J.; Feng, Y. H.; Zhang, Z.; Wu, T.; Chen, H. Y., Small 2011, 7 (19), 2721-2726.
  8. Measuring Ensemble-Averaged Surface-Enhanced Raman Scattering in the Hotspots of Colloidal Nanoparticle Dimers and Trimers, Chen, G.; Wang, Y.; Yang, M. X.; Xu, J.; Goh, S. J.; Pan, M.; Chen, H. Y., J. Am. Chem. Soc. 2010, 132 (11), 3644-3645.
  9. A Systems Approach towards the Stoichiometry-Controlled Hetero-Assembly of Nanoparticles, Wang, Y.; Chen, G.; Yang, M. X.; Silber, G.; Xing, S. X.; Tan, L. H.; Wang, F.; Feng, Y. H.; Liu, X. G.; Li, S. Z.; Chen, H. Y., Nat. Commun. 2010, 1, 87.
  10. Scalable Routes to Janus Au-SiO2 and Ternary Ag-Au-SiO2 Nanoparticles, Chen, T.; Chen, G.; Xing, S. X.; Wu, T.; Chen, H. Y., Chem. Mater. 2010, 22 (13), 3826-3828.
  11. Mechanistic Investigation into the Spontaneous Linear Assembly of Gold Nanospheres, Yang, M. X.; Chen, G.; Zhao, Y. F.; Silber, G.; Wang, Y.; Xing, S. X.; Han, Y.; Chen, H. Y., PCCP 2010, 12 (38), 11850-11860.
  12. Hotspot-Induced Transformation of Surface-Enhanced Raman Scattering Fingerprints, Chen, T.; Wang, H.; Chen, G.; Wang, Y.; Feng, Y. H.; Teo, W. S.; Wu, T.; Chen, H. Y., ACS Nano 2010, 4 (6), 3087-3094.
  13. High-Purity Separation of Gold Nanoparticle Dimers and Trimers, Chen, G.; Wang, Y.; Tan, L. H.; Yang, M. X.; Tan, L. S.; Chen, Y.; Chen, H. Y., J. Am. Chem. Soc. 2009, 131 (12), 4218-4219.
  14. Fabrication of Polymer Nanocavities with Tailored Openings, Tan, L. H.; Xing, S. X.; Chen, T.; Chen, G.; Huang, X.; Zhang, H.; Chen, H. Y., ACS Nano 2009, 3 (11), 3469-3474.
  15. Fabrication of Hydrophobic Fluorinated Amorphous Carbon Thin Films by an Electrochemical Route, Chen, G.; Zhang, J. Y.; Yang, S. R., Electrochem. Commun. 2008, 10 (1), 7-11.
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