{"id":27,"date":"2017-02-09T10:34:57","date_gmt":"2017-02-09T15:34:57","guid":{"rendered":"https:\/\/sciencescosmaincms.cm.ucf.edu\/chemistry\/yuanlab\/?page_id=27"},"modified":"2017-02-09T13:59:06","modified_gmt":"2017-02-09T18:59:06","slug":"research","status":"publish","type":"page","link":"https:\/\/sciences.ucf.edu\/chemistry\/yuanlab\/research\/","title":{"rendered":"Research Interest"},"content":{"rendered":"

An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3+2]-cycloaddition was achieved in our laboratories. This protocol demonstrates excellent enantio- and diastereoselectivity with broad functional group tolerance. A diverse range of spiroindolines were prepared by this approach and the products served as ideal substrates for C2 derivatization.<\/p>\n

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A highly stereoselective and scalable synthesis of\u00a0l-allo-enduracididine from hydroxyproline derivative was recently disclosed by us. Pyrrolidine oxidation and reductive ring opening are the key steps in the synthesis. Compared to previously reported approaches, current route affords\u00a0l-allo-enduracididine in 10 steps from\u00a0Boc-trans<\/em>-Hyp-Ot<\/em>Bu in 31% overall yield with >50:1 diastereoselectivity.<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3+2]-cycloaddition was achieved in our laboratories. This protocol demonstrates…<\/p>\n","protected":false},"author":3,"featured_media":86,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-27","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nResearch Interest - The Yuan Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sciences.ucf.edu\/chemistry\/yuanlab\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Interest - The Yuan Lab\" \/>\n<meta property=\"og:description\" content=\"An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3+2]-cycloaddition was achieved in our laboratories. 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