{"id":31,"date":"2017-02-09T10:38:59","date_gmt":"2017-02-09T15:38:59","guid":{"rendered":"https:\/\/sciencescosmaincms.cm.ucf.edu\/chemistry\/yuanlab\/?page_id=31"},"modified":"2024-02-23T12:54:59","modified_gmt":"2024-02-23T17:54:59","slug":"work-completed-at-ucf","status":"publish","type":"page","link":"https:\/\/sciences.ucf.edu\/chemistry\/yuanlab\/work-completed-at-ucf\/","title":{"rendered":"Work Completed at UCF"},"content":{"rendered":"

Selected Journal Articles<\/h4>\n

Bobek, K. B.; Ezzat, N. S.; Jones, B. S.; Bian, Y.; Shaw, T. E.; Jurca, T.; Li, H.*; Yuan, Y.*, Total Synthesis of Polysubstituted \u03b3-Butyrolactone Lignans (\u2212)-Hinokinin, (\u2212)-Bicubebin B, and (\u2212)-Isodeoxypodophyllotoxin via Oxime Carbonate Formation. Org. Lett.<\/em> 2023<\/strong>, 25, 31. Link<\/a><\/p>\n

\"\"<\/p>\n

Bian, Y.; Alem, D.; Beato, F.; Hogenson, T. L.; Yang, X.; Jiang, K.; Cai, J.; Ma, W. W.; Fernandez-Zapico, M.; Tan, A. C.; Lawrence, N. J.; Fleming, J. B.; Yuan, Y.*; Xie, H.*, Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer. J. Med. Chem.<\/em> 2022<\/strong>, 65, 16432. Link<\/a><\/p>\n

\"\"<\/p>\n

Huang, G., Solano, C.M., Melendez, J., Yu-Alfonzo, S., Boonhok, R., Min, H., Miao, J., Chakrabarti, D.*, Yuan, Y.* Discovery of Fast-Acting Dual-Stage Antimalarial Agents by Profiling Pyridylvinylquinoline Chemical Space via Copper Catalyzed Azide-Alkyne Cycloadditions, Eur. J. Med. Chem.<\/em>, 2021<\/strong>, 112889. Link<\/a><\/p>\n

\"\"<\/p>\n

Huang, G., Solano, G.M., Melendez, J., Shaw, J., Collins, J., Banks, R., Arshadi, A.K., Boonhok, R., Min, H., Miao, J., Chakrabarti, D.*, Yuan, Y.* Synthesis, Structure\u2212Activity Relationship, and Antimalarial Efficacy of 6\u2011Chloro-2-arylvinylquinolines. J. Med. Chem<\/em>., 2020<\/strong>, 11756. Link<\/a><\/p>\n

\"\"<\/p>\n

Jin, K., Sam, I.H., Po, H.L., Lin, D., Ghazvini Zadeh, E.H., Chen, S*, Yuan, Y.*, Li, X.* Total Synthesis of Teixobactin. Nat. Commun<\/em>.,\u00a02016<\/strong>, 7:12394 doi: 10.1038\/ ncomms12394. Link<\/a><\/p>\n

\"Publication<\/p>\n

Logan, M.W.; Yuen, A.L.; Zheng, Y.; Hall, E.A. Hettinger, M.A.; Marks, R.M.; Hosler, M.L.; Rossi, F.M.; Yuan, Y.*; Uribe-Romo, F.* Heterogeneous Photoredox Synthesis of N-hydroxy-oxazolidinones Catalyzed by Metal-Organic Frameworks. Catal. Sci. Technol<\/em>.,\u00a02016<\/strong>, 5647-5655. Link<\/a><\/p>\n

\"\"<\/p>\n

Zheng, Y.; Zadeh, E.H.G.; Yuan, Y.* One-Pot, Enantioselective Synthesis of 2,3-Dihydroazulen-6(1H)-one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes. \u200eEur. J. Org. Chem<\/em>.\u00a02016<\/strong>\uff0c<\/span>2115-2119. Link<\/a><\/p>\n

\"\"<\/p>\n

Craig, W.; Chen, J. Richardson, D.; Thorpe, R., Yuan, Y.* A Highly Stereoselective and Scalable Synthesis of L-allo-Enduracididine. Org. Lett.,<\/em>2015<\/strong>, 17, 4620-4623. Link<\/a><\/p>\n

\"\"<\/p>\n

Zheng, Y.; Cleaveland, J.; Richardson, D.; Yuan, Y.* An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure\u2212Activity Relationship (SAR) Study at C2 Position. Org. Lett.,<\/em> 2015<\/strong>, 17, 4240-4243. Link<\/a><\/p>\n

\"\"<\/p>\n

Book Chapter<\/h4>\n

1. Yuan, Y.*; Wang, W. Post-Synthetic Chemical Modification of Oligonucleotides. Volume 9, Comprehensive Organic Synthesis, Ed.<\/em> 2, 463-493, 2014<\/strong>. Link<\/a>.<\/p>\n

Prior to UCF<\/h3>\n

Journal Articles<\/h4>\n

24. Zewge, D.; Gosselin, F.; Tellers, D.M.; Davies, I.W.; Jadhav, V.; Nerurkar, S.S.; Yuan, Y.; Li, J.; Flanagan, W.M., Kenski, D.M. High-Throughput Chemical Modification of Oligonucleotides for Systematic Structure-Activity Relationship Evaluation. Bioconjugate Chem.<\/em>, 2014, 25, 2222.<\/p>\n

23. Janout, V.; Cline, L.L.; Feuston, B.P.; Klein, L.; O’Brien, A.; Tucker, T.; Yuan, Y.; O’Neill-Davis, L.A.; Peiffer, R.L.; Nerurkar, S.S.; Jadhav, V.; Tellers, D.M., Regen, S.L. Molecular Umbrella Conjugate for the Ocular Delivery of siRNA. Bioconjugate Chem.<\/em>, 2014, 25, 197.<\/p>\n

22. Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X., Danishefsky, S.J. Encouraging Progress in the omega-Aspartylation of Complex Oligosaccharides as a General Route to beta-N-Linked Glycopolypeptides. J. Am. Chem. Soc.<\/em>, 2011, 133, 1597.<\/p>\n

21. Aaronson, J.G.; Klein, L.J.; Momose, A.A.; O’Brien, A.M.; Shaw, A.W.; Tucker, T.J.; Yuan, Y., Tellers, D.M. Rapid HATU-Mediated Solution Phase siRNA Conjugation. Bioconjugate Chem.<\/em>, 2011, 22, 1723.<\/p>\n

20. Yuan, Y.; Chen, J.; Wan, Q.; Wilson, R.M., Danishefsky, S.J. Toward Fully Synthetic, Homogeneous Glycoproteins: Advances in Chemical Ligation. Biopolymers<\/em>, 2010, 94, 373.<\/p>\n

19. Joo, J.M.; David, R.A.; Yuan, Y., Lee, C. Concise Synthesis of the Erythrina Alkaloid 3-Demethoxyerythratidinone via Combined Rhodium Catalysis. Org. Lett.<\/em>, 2010, 12, 5704.<\/p>\n

18. Yuan, Y.; Zhu, J.; Li, X.; Wu, X., Danishefsky, S.J. Preparation and reactions of Nthioformyl peptides from amino thioacids and isonitriles. Tetrahedron Lett.<\/em>, 2009, 50, 2329.<\/p>\n

17. Yuan, Y.; Chen, J.; Wan, Q.; Tan, Z.; Chen, G.; Kan, C., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys(29)-Gly(77) Glycopeptide Domain. J. Am. Chem. Soc.<\/em>, 2009, 131, 5432.<\/p>\n

16. Wu, X.; Yuan, Y.; Li, X., Danishefsky, S.J. Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry. Tetrahedron Lett.<\/em>, 2009, 50, 4666.<\/p>\n

15. Wang, P.; Zhu, J.; Yuan, Y., Danishefsky, S.J. Total Synthesis of the 2,6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc.<\/em>, 2009, 131, 16669.<\/p>\n

14. Tan, Z.; Shang, S.; Halkina, T.; Yuan, Y., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Non-NCL-Based Chemical Synthesis of the Gln(78)-Arg(166) Glycopeptide Domain. J. Am. Chem. Soc.<\/em>, 2009, 131, 5424.<\/p>\n

13. Kan, C.; Trzupek, J.D.; Wu, B.; Chen, G.; Tan, Z.; Yuan, Y., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala(1)-Gly(28) Glycopeptide Domain by “Alanine” Ligation. J. Am. Chem. Soc.<\/em>, 2009, 131, 5438.<\/p>\n

12. Wan, Q.; Chen, J.; Yuan, Y., Danishefsky, S.J. Oxo-ester Mediated Native Chemical Ligation: Concept and Applications. J. Am. Chem. Soc.<\/em>, 2008, 130, 15814.<\/p>\n

11. Li, X.; Yuan, Y.; Kan, C., Danishefsky, S.J. Addressing Mechanistic Issues in the Coupling of Isonitriles and Carboxylic Acids: Potential Routes to Peptidic Constructs. J. Am. Chem. Soc.<\/em>, 2008, 130, 13225.<\/p>\n

10. Li, X.; Yuan, Y.; Berkowitz, W.F.; Todaro, L.J., Danishefsky, S.J. On the TwoComponent Microwave-Mediated Reaction of Isonitriles with Carboxylic Acids: Regarding Alleged Formimidate Carboxylate Mixed Anhydrides. J. Am. Chem. Soc.<\/em>, 2008, 130, 13222.<\/p>\n

9. Chen, J.; Wan, Q.; Yuan, Y.; Zhu, J., Danishefsky, S.J. Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis. Angew. Chem., Int. Ed.<\/em>, 2008, 47, 8521.<\/p>\n

8. Yuan, Y.; Lai, A.J.; Kraml, C.M., Lee, C. A highly Enantio- and Diastereoselective 1,3-Dimethylallylation of Aldehydes. Tetrahedron<\/em>, 2006, 62, 11391.<\/p>\n

7. Joo, J.M.; Yuan, Y., Lee, C. Tandem Cyclization of Alkynes via Rhodium Alkynyl and Alkenylidene Catalysis. J. Am. Chem. Soc.<\/em>, 2006, 128, 14818.<\/p>\n

6. Yuan, Y.; Men, H.B., Lee, C.B. Total Synthesis of Kendomycin: A Macro-CGlycosidation Approach. J. Am. Chem. Soc.<\/em>, 2004, 126, 14720.<\/p>\n

Patents<\/h4>\n

5. Danishefsky, S. J.; David, J. D.; Chen, J.; Wu, B.; Chen, G.; Wan, Q.; Tan, Z.; Kan, C.; Yuan, Y.; Hua, Z.; Ranganathan, K.; Trzupek, J. D. Preparation of Homogeneous Erythropoietin and Other Peptides and Proteins. WO 2007\/120614 A2 20071025<\/p>\n

4. Aaronson, J.G.; Barnett, S.F.; Bartz, R.; Colletti, S.L.; Jadhav, V.R.; Momose, A.A.; Shaw, A.W.; Tellers, D.M.; Tucker, T.J.; Wang, W.; Yuan, Y. Novel Single Chemical Entities and Methods for Delivery of Oligonucleotides. WO 2011\/126974<\/p>\n

3. Colletti, S.L.; Gosselin, F.; Jadhav, V.R.; Shaw, A.W.; Tellers, D.M.; Tucker, T.J.; Yuan, Y.; Zewge, D. Novel Single Chemical Entities and Methods for Delivery of Oligonucleotides. WO 2012\/030683<\/p>\n

2. Tellers, D. M.; Colletti, S. L.; Dudkin, V.; Aaronson, J.; Momose, A.; Tucker, T. J.; Yuan, Y.; Calati, K. B.; Tian, L.; Parmar, R. G.; Shaw, A. W.; Wang, W.; Storr, R. A.; Busuek, M.; Kowtoniuk, R. A. Novel TetraGalNAc and Peptide Containing Conjugates and Methods for Delivery of Oligonucleotides. WO 2013166155<\/p>\n

1. Tellers, D. M.; Colletti, S. L.; Dudkin, V.; Ikemoto, N.; Liao, H.; Parish, C.; Pei, T.; Shaw, A. W.; Truong, Q.; Wang, L.; Yuan, Y.; Zhu, M. Novel TetraGalNAc Containing Conjugates and Methods for Delivery of Oligonucleotides. WO 2013166121<\/p>\n","protected":false},"excerpt":{"rendered":"

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