{"id":25263,"date":"2019-09-30T14:25:33","date_gmt":"2019-09-30T18:25:33","guid":{"rendered":"https:\/\/sciencescosmaincms.cm.ucf.edu\/news\/?p=25263"},"modified":"2020-02-13T11:28:40","modified_gmt":"2020-02-13T16:28:40","slug":"nih-awards-ucf-researcher-3-8-million-to-study-opiate-overdoses","status":"publish","type":"post","link":"https:\/\/sciences.ucf.edu\/news\/nih-awards-ucf-researcher-3-8-million-to-study-opiate-overdoses\/","title":{"rendered":"NIH Awards UCF Researcher $3.8 Million to Study Opiate Overdoses"},"content":{"rendered":"<p>&nbsp;<\/p>\n<div id=\"attachment_25264\" style=\"width: 1210px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-25264\" class=\"wp-image-25264 size-full\" src=\"https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full.jpg\" alt=\"\" width=\"1200\" height=\"800\" srcset=\"https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full.jpg 1200w, https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full-300x200.jpg 300w, https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full-768x512.jpg 768w, https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full-1024x683.jpg 1024w, https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hickman_Full-299x199.jpg 299w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><p id=\"caption-attachment-25264\" class=\"wp-caption-text\">Professor Hickman and his team of students is ready to look at opiate overdosing and its impact on the body.<\/p><\/div>\n<p>BY ZENAIDA GONZALEZ KOTALA<\/p>\n<p>The National Institutes of Health (NIH) today announced that UCF will receive a $3.8 million milestone based grant to better understand how overdosing on opiates works, their impact on multiple organs and the effect of drugs used to treat overdoses, including potential toxicity of organs.<\/p>\n<p>James Hickman, a professor at UCF\u2019s NanoScience Technology Center, is the lead scientist on the proposal. He\u2019s developed a human-on-a-chip in vitro system that mimics multiple human organs. The technology will allow him to conduct this work without harming patients or animals. He developed the system at UCF in collaboration with Michael Shuler at Cornell University. UCF has licensed the technology to Hesperos, a company Hickman co-founded and where he serves as chief scientist.<\/p>\n<p>While many organizations are researching the impact of opiates, UCF\u2019s team was selected because it can do it via this artificial human-on-a-chip multiple organ systems. The technology could help replace animal testing in the future by providing a platform to conduct pharmaceutical research with validated success, Hickman says.<\/p>\n<p><a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-funds-945-million-research-tackle-national-opioid-crisis-through-nih-heal-initiative\">The new funding comes from the NIH\u2019s Helping to End Addiction Long-term Initiative, or NIH HEAL.<\/a>\u00a0The initiative aims to improve treatments for chronic pain, curb the rates of opioid use disorder and overdose, and achieve long-term recovery from opioid addiction.<\/p>\n<p>\u201cWe are grateful to have funding to support research in an area that represents such a large and growing need,\u201d Hickman says. \u201cOur interconnected human-on-a-chip system provides a non-invasive way to emulate the response of compounds among all \u2018organ\u2019 compartments, and to concurrently predict potential toxicity and efficacy of drugs, including opioids and opioid antagonists such as Narcan.\u201d<\/p>\n<p>UCF\u2019s award is one of 375 grants across 41 states made by the National Institutes of Health in the fiscal year 2019 to apply scientific solutions to reverse the national opioid crisis.<\/p>\n<div id=\"attachment_25265\" style=\"width: 310px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-25265\" class=\"wp-image-25265 size-medium lazyload\" data-src=\"https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hesperos-HoaC-system-300x200-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" data-srcset=\"https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hesperos-HoaC-system-300x200.jpg 300w, https:\/\/sciences.ucf.edu\/news\/wp-content\/uploads\/sites\/29\/2019\/09\/Hesperos-HoaC-system-300x200-299x199.jpg 299w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/200;\" \/><p id=\"caption-attachment-25265\" class=\"wp-caption-text\">While many organizations are researching the impact of opiates, UCF\u2019s team was selected because it can do it via this artificial human-on-a-chip multiple organ systems. The technology could help replace animal testing in the future by providing a platform to conduct pharmaceutical research with validated success, Hickman says.<\/p><\/div>\n<p>\u201cIt\u2019s clear that a multi-pronged scientific approach is needed to reduce the risks of opioids, accelerate the development of effective non-opioid therapies for pain and provide more flexible and effective options for treating addiction to opioids,\u201d says NIH Director Francis S. Collins, who <a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-launches-heal-initiative-doubles-funding-accelerate-scientific-solutions-stem-national-opioid-epidemic\">launched<\/a>\u00a0the initiative in early 2018. \u201cThis unprecedented investment in the NIH HEAL Initiative demonstrates the commitment to reversing this devastating crisis.\u201d<\/p>\n<p>Hickman\u2019s work will provide insight into the impact of opiate overdoses and treatment drugs on the kidneys, heart, muscles and liver as well as explore how these drugs impact the part of the brain that controls breathing which is effected during overdose situations. He will also look at the impact of Narcan \u2014 a drug to treat overdoses \u2013 on these same systems.<\/p>\n<p>The NIH has also previously funded Hesperos to advance the human-on-a-chip technology. A major milestone was in 2018 when the National Center for Advancing Translational Science at the NIH awarded Hesperos a Phase IIb $4 million three-year Small Business Innovation Research grant to increase the capacity and automation of this novel synthetic organ system.<\/p>\n<p>Hesperos provides pharmaceutical, government and nonprofit organizations contract research services utilizing the human-on-a-chip system for disease modeling and drug testing.<\/p>\n<p>Hickman has multiple degrees from MIT and Pennsylvania State University. He has published over 100 peer-reviewed papers, has been awarded 28 patents and has joint appointments at UCF in chemistry, engineering and biomedical sciences. He runs the <a href=\"http:\/\/nanoscience.ucf.edu\/hickman\/\">Hybrid Systems Lab<\/a>\u00a0at UCF, which studies the interface between biological and non-biological systems to construct next-generation systems for toxicology, drug discovery and basic biology research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; BY ZENAIDA GONZALEZ KOTALA The National Institutes of Health (NIH) today announced that UCF will receive a $3.8 million milestone based grant to better understand how overdosing on opiates works, their impact on multiple organs and the effect of drugs used to treat overdoses, including potential toxicity of organs. James Hickman, a professor at [&hellip;]<\/p>\n","protected":false},"author":137,"featured_media":25264,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[35,38,5967,5377,28,29],"tags":[1726,6074,6075],"class_list":["post-25263","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chemistry-departments","category-breaking-news","category-notables","category-research","category-top-news","category-ucf-news","tag-james-hickman","tag-national-institute-of-health-nih","tag-ucf-nanonscience-technology-center"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NIH Awards UCF Researcher $3.8 Million to Study Opiate Overdoses - College of Sciences News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sciences.ucf.edu\/news\/nih-awards-ucf-researcher-3-8-million-to-study-opiate-overdoses\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIH Awards UCF Researcher $3.8 Million to Study Opiate Overdoses - College of Sciences News\" \/>\n<meta property=\"og:description\" content=\"&nbsp; BY ZENAIDA GONZALEZ KOTALA The National Institutes of Health (NIH) today announced that UCF will receive a $3.8 million milestone based grant to better understand how overdosing on opiates works, their impact on multiple organs and the effect of drugs used to treat overdoses, including potential toxicity of organs. 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