{"id":2608,"date":"2012-05-10T10:17:00","date_gmt":"2012-05-10T13:17:00","guid":{"rendered":"http:\/\/news.cos.ucf.edu\/?p=2608"},"modified":"2012-05-10T10:17:00","modified_gmt":"2012-05-10T13:17:00","slug":"chemistry-research-published-in-journal-of-the-american-chemical-society","status":"publish","type":"post","link":"https:\/\/sciences.ucf.edu\/news\/chemistry-research-published-in-journal-of-the-american-chemical-society\/","title":{"rendered":"Chemistry Team devlops probes that may be useful to study Parkinson&#8217;s and Alzheimer&#8217;s diseases"},"content":{"rendered":"<p><em><strong>Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides<\/strong><\/em><\/p>\n<p>Oxidative stress is thought to play a key role in a number of conditions, cardiovascular aging, Parkinson\u2019s disease, and Alzheimer\u2019s disease.  With the increasing prevalence of these diseases, there are few methods to monitor molecular components that cause oxidative stress in vivo. \u00a0<strong>Prof. Kevin D. Belfield and his team<\/strong> developed a series of molecular probes that detect key reactive species in the oxidative stress process and \u201clight up\u201d in the presence of oxidative stress species.  Significantly, they report the first demonstration of oxidative stress visualization of these reactive species by two-photon fluorescence imaging, providing a promising path for translation of these findings for in vivo oxidative stress imaging.\u00a0The research, led by <strong>Prof. Kevin D. Belfield<\/strong>, UCF Chemistry chair, was published recently in the Journal of the American Chemical Society and involved two students in the Chemistry PhD program (Hyo-Yang Ahn, graduated in August 2011 and Bosung Kim, a current student).<\/p>\n<p>Full reference:<br \/>\nAhn, H.-Y.; Fairfull-Smith, K. E.; Morrow, B. J.; Lussini, V.; Kim, B.; Bondar, M. V.; Bottle, S. E.; Belfield, K. D. \u201cTwo-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides\u201d Journal of the American Chemical Society 2012, 134, 4721-4730.<\/p>\n<p>Dr. Belfield&#8217;s research interests are in multiphoton absorbing materials, supramolecular materials, two-photon photochemistry, two-photon 3D optical data storage, multiphoton fluorescent probes and multiphoton bioimaging for early tumor detection and image guided surgery, photodynamic therapy agents, nanostructured functional organic and polymeric materials, and photochromic materials. His research has been funded by NSF, NIH, US Civilian Research &amp; Development Foundation, Research Corporation, The Petroleum Research Fund, AFOSR, US Army, DARPA, and industry.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides Oxidative stress is thought to play a key role in a number of conditions, cardiovascular aging, Parkinson\u2019s disease, and Alzheimer\u2019s disease. With the increasing prevalence of these diseases, there are few methods to monitor molecular components that cause oxidative stress in vivo. \u00a0Prof. Kevin [&hellip;]<\/p>\n","protected":false},"author":122,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[35,13,28],"tags":[],"class_list":["post-2608","post","type-post","status-publish","format-standard","hentry","category-chemistry-departments","category-news","category-top-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chemistry Team devlops probes that may be useful to study Parkinson&#039;s and Alzheimer&#039;s diseases - College of Sciences News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sciences.ucf.edu\/news\/chemistry-research-published-in-journal-of-the-american-chemical-society\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemistry Team devlops probes that may be useful to study Parkinson&#039;s and Alzheimer&#039;s diseases - College of Sciences News\" \/>\n<meta property=\"og:description\" content=\"Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides Oxidative stress is thought to play a key role in a number of conditions, cardiovascular aging, Parkinson\u2019s disease, and Alzheimer\u2019s disease. With the increasing prevalence of these diseases, there are few methods to monitor molecular components that cause oxidative stress in vivo. \u00a0Prof. Kevin [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sciences.ucf.edu\/news\/chemistry-research-published-in-journal-of-the-american-chemical-society\/\" \/>\n<meta property=\"og:site_name\" content=\"College of Sciences News\" \/>\n<meta property=\"article:published_time\" content=\"2012-05-10T13:17:00+00:00\" \/>\n<meta name=\"author\" content=\"jerriann.sullivan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jerriann.sullivan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/\"},\"author\":{\"name\":\"jerriann.sullivan\",\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/a58d50998b0df974ea6fc70a24e37019\"},\"headline\":\"Chemistry Team devlops probes that may be useful to study Parkinson&#8217;s and Alzheimer&#8217;s diseases\",\"datePublished\":\"2012-05-10T13:17:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/\"},\"wordCount\":292,\"articleSection\":[\"Chemistry\",\"News\",\"Top News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/\",\"url\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/\",\"name\":\"Chemistry Team devlops probes that may be useful to study Parkinson's and Alzheimer's diseases - College of Sciences News\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/#website\"},\"datePublished\":\"2012-05-10T13:17:00+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/a58d50998b0df974ea6fc70a24e37019\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/chemistry-research-published-in-journal-of-the-american-chemical-society\\\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/\",\"name\":\"College of Sciences News\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/sciences.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/a58d50998b0df974ea6fc70a24e37019\",\"name\":\"jerriann.sullivan\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/?s=96&d=mm&r=g\",\"caption\":\"jerriann.sullivan\"},\"url\":\"\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Chemistry Team devlops probes that may be useful to study Parkinson's and Alzheimer's diseases - College of Sciences News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sciences.ucf.edu\/news\/chemistry-research-published-in-journal-of-the-american-chemical-society\/","og_locale":"en_US","og_type":"article","og_title":"Chemistry Team devlops probes that may be useful to study Parkinson's and Alzheimer's diseases - College of Sciences News","og_description":"Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides Oxidative stress is thought to play a key role in a number of conditions, cardiovascular aging, Parkinson\u2019s disease, and Alzheimer\u2019s disease. 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