{"id":6609,"date":"2013-03-07T13:20:00","date_gmt":"2013-03-07T18:20:00","guid":{"rendered":"http:\/\/news.cos.ucf.edu\/?p=6609"},"modified":"2013-03-07T13:20:00","modified_gmt":"2013-03-07T18:20:00","slug":"killing-cancer-cells-with-acid-reflux","status":"publish","type":"post","link":"https:\/\/sciences.ucf.edu\/news\/killing-cancer-cells-with-acid-reflux\/","title":{"rendered":"Killing Cancer Cells with Acid Reflux"},"content":{"rendered":"

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells \u2013 give them acid reflux.\u00a0\"Screen<\/a><\/p>\n

Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic \u2013 similar to the way greasy foods cause acid reflux in some people. He used a light-activated, acid-generating molecule to make the cells more acidic when exposed to specific wavelengths of light, which in turn kills the bad cells. The surrounding healthy cells stay intact.<\/p>\n

The technique is a simple way around a problem that has frustrated researchers for years. For photodynamic therapy (the special laser-light treatment) to work, cancer cells loaded with photosensitizers need oxygen to trigger the fatal reaction. But by their very nature, most cancer cells lack oxygen. Nonetheless, scientists were intent on making the photodynamic system work because it offers a way to target cancer cells deep within human tissue without causing a lot of collateral damage.<\/p>\n

Instead of focusing on oxygen, Belfield flipped the problem around and found another way to poison the bad cells, while protecting the healthy ones.<\/p>\n

\u201cIt\u2019s the first time we\u2019ve found a way around the oxygen problem,\u201d Belfield said. \u201cThis work is truly ground breaking. It should eventually provide a therapeutic means to treat certain types of cancers with minimal side effects. It should also be a very useful tool for cell biologists and biomedical researchers. It could even find a place in treating other diseases such as neurodegenerative diseases.\u201d<\/p>\n

His work was recently published in the\u00a0Journal of the American Chemical Society<\/a>.<\/p>\n

Belfield and his team at UCF used human colorectal carcinoma cells for the study, which was funded by the National Science Foundation and the National Institutes for Health. More research is needed to determine that there are no serious side affects in humans and whether the technique will work on a variety of cancers, but Belfield is optimistic.<\/p>\n

\u201cPredicting commercialization is difficult at best,\u201d he said. \u201cBut we are well situated to forge ahead\u201d.<\/p>\n

So how did Belfield come up with such an \u201coutside the box\u201d approach? His other non-medical related research was the inspiration.<\/p>\n

Belfield has developed a three-dimensional, optical data-storage system, which involves the use of acid generators. About six years ago he wondered if his approach could have applications in medical therapy.<\/p>\n

\u201cIt took about five years to get someone in my research group interested to take on the unorthodox project,\u201d Belfield said. \u201cBut it seems to have paid off.<\/p>\n

Other contributors to the research are Xiling Yue, Ciceron O. Yanez and Sheng Yao, researchers and students at UCF students focusing on chemistry or photonics.<\/p>\n

Belfield is one of the pioneers in two-photon absorbing materials, two-photon photochemistry, and two-photon photophysics. His research spans a number of disciplines including organic, polymer, and physical chemistry, as well as optics, optical microscopy, and bioimaging. His research has potential applications in everything from the way people store data on DVDs to fighting cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells \u2013 give them acid reflux.\u00a0 Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic \u2013 similar to the way greasy foods cause acid reflux in some people. He used a light-activated, acid-generating […]<\/p>\n","protected":false},"author":122,"featured_media":6618,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[35,13,28],"tags":[],"class_list":["post-6609","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chemistry-departments","category-news","category-top-news"],"yoast_head":"\nKilling Cancer Cells with Acid Reflux - College of Sciences News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sciences.ucf.edu\/news\/killing-cancer-cells-with-acid-reflux\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Killing Cancer Cells with Acid Reflux - College of Sciences News\" \/>\n<meta property=\"og:description\" content=\"A University of Central Florida chemist has come up with a unique way to kill certain cancer cells \u2013 give them acid reflux.\u00a0 Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic \u2013 similar to the way greasy foods cause acid reflux in some people. 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