{"id":24,"date":"2020-06-23T14:28:12","date_gmt":"2020-06-23T18:28:12","guid":{"rendered":"https:\/\/sciencescosmaincms.cm.ucf.edu\/physics\/kang-group\/?page_id=24"},"modified":"2020-06-29T21:34:42","modified_gmt":"2020-06-30T01:34:42","slug":"research","status":"publish","type":"page","link":"https:\/\/sciences.ucf.edu\/physics\/kang-group\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<h3>Multi-scale investigation of actin biomechanics and mechanobiology<\/h3>\n<p><img decoding=\"async\" class=\"wp-image-132 alignleft lazyload\" data-src=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Figure-1.jpg\" alt=\"\" width=\"504\" height=\"211\" data-srcset=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Figure-1.jpg 545w, https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Figure-1-300x126.jpg 300w\" data-sizes=\"(max-width: 504px) 100vw, 504px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 504px; --smush-placeholder-aspect-ratio: 504\/211;\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"text-decoration: underline;color: #000080\">Thermally fluctuating filament in crowded conditions<\/span><\/p>\n<div style=\"width: 104px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-24-1\" width=\"104\" height=\"112\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Jp8b12320-Si-003.mp4?_=1\" \/><a href=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Jp8b12320-Si-003.mp4\">https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/Jp8b12320-Si-003.mp4<\/a><\/video><\/div>\n<p>(<em>Source<\/em>: Castaneda <em>et al<\/em>. (2019) <em>J. Phys. Chem. B<\/em>)<\/p>\n<p>The self-assembly of protein actin into semi-flexible double helical filaments and bundles or networks drives many important cellular processes, which take place in a crowded and confined cytoplasm. Despite increased appreciation of macromolecular crowding effects, it is not well understood how crowded intracellular environments, along with altering ionic and osmotic conditions, modulate cytoskeletal filament mechanics and structure.<\/p>\n<p>We aim to 1) determine how mechanics and conformations of actin filaments and crosslinked bundles are modulated in crowded environments at the nanoscale, 2) evaluate filament assembly dynamics and interactions with actin crosslinking proteins in crowded environments, and 3) determine how actin cytoskeleton responds to geometric constraints, mechanical forces, and cellular environmental factors, in addition to osmotic stress. By combining molecular biophysics and nanoscale characterization, our work will transform the understanding of cell physiology and disease states in terms of the mechanisms that control the physicochemical, mechanical, and structural properties of actin cytoskeleton.<\/p>\n<hr \/>\n<div>\n<div style=\"text-align: left;padding-left: 40px\">Our research is supported by the <strong>National Science Foundation<\/strong>, the <strong>National Institute of Health<\/strong>, and <strong>NASA Florida Space Grant Consortium<\/strong>. <em>Thank you!<\/em><\/div>\n<div><img decoding=\"async\" class=\"wp-image-139 size-thumbnail alignleft lazyload\" data-src=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/NSF-logo-150x150.jpeg\" alt=\"\" width=\"150\" height=\"150\" data-srcset=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/NSF-logo-150x150.jpeg 150w, https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/NSF-logo.jpeg 224w\" data-sizes=\"(max-width: 150px) 100vw, 150px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 150px; --smush-placeholder-aspect-ratio: 150\/150;\" \/><img decoding=\"async\" class=\"wp-image-140 size-thumbnail alignleft lazyload\" data-src=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/FSGC-logo-150x150.jpeg\" alt=\"\" width=\"150\" height=\"150\" data-srcset=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/FSGC-logo-150x150.jpeg 150w, https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/FSGC-logo.jpeg 225w\" data-sizes=\"(max-width: 150px) 100vw, 150px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 150px; --smush-placeholder-aspect-ratio: 150\/150;\" \/><img decoding=\"async\" class=\"wp-image-141 size-medium alignleft lazyload\" data-src=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/nih-logo-300x114.png\" alt=\"\" width=\"300\" height=\"114\" data-srcset=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/nih-logo-300x114.png 300w, https:\/\/sciences.ucf.edu\/physics\/kang-group\/wp-content\/uploads\/sites\/30\/2020\/06\/nih-logo.png 364w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/114;\" \/><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Multi-scale investigation of actin biomechanics and mechanobiology &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Thermally fluctuating filament in crowded conditions (Source: Castaneda et al. (2019) J. <a class=\"mh-excerpt-more\" href=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/research\/\" title=\"Research\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":60,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-24","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Kang Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sciences.ucf.edu\/physics\/kang-group\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Kang Research Group\" \/>\n<meta property=\"og:description\" content=\"Multi-scale investigation of actin biomechanics and mechanobiology &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Thermally fluctuating filament in crowded conditions (Source: Castaneda et al. 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