Links to all papers published by PI can be found at Google Scholar

Publications from NOx Nation

26. Shultz-Johnson, L.R.; Chang, M.; Bisram, N.N.; Bryant, J.T.; Martin, C.P.; Rahmani, A.; Furst, J.I.; Caranto, J.D.; Banerjee, P.; Uribe-Romo, F.J.; Gamelin, D.R.; and Jurca, T. Multivariate Analysis on the Structure−Activity Parameters for 2 Nano-CuOx‑Catalyzed Reduction Reactions ACS Appl. Nano Mater. 2024, Accepted.

25. Bryant, J.T,; Logan, M.W.; Chen, X.; Djokic, M.; Cairnie, D.R.; Vazquez-Molina, D.A.; Nijamudheen, A.; Langlois, K.R.; Markley, M.J.; Pombar, G.; Holland, A.A.; Caranto, J.D.; Harper, J.K; Morris, A.J.;* Mendoza-Cortes, J.L.;* Jurca, T.;* Chapman, K.;* Uribe-Romo, F.J. Synergistic Steric and Electronic Effects on the Photoredox Catalysis by a Multivariate Library of Titania Metal–Organic Frameworks J. Am. Chem. Soc. 2023, 145, 4589-4600. DOI: 10.1021/jacs.2c12147

24. Nix, C.A.; Nottolini, I.; Caranto, J.D.; Gerasimova, Y.; Kolpashchikov, D.; Saitta, E.K.H. Championing the Involvement of Practitioners in the Biochemistry Educational Research Process: A Phenomenological View of the Early Stages of Collaborative Action Research. Int. J. High. Educ. 2022, 11, 114-139.

23. Strickland, K.A.; Holland, A.A.; Trudeau, A.; Szlamkowicz, I.; Beazley, M.J.; Anagnostopoulos, V.A.; Graham, D.A.; Caranto. J.D. Reduction of a Heme Cofactor Initiates N-Nitroglycine Degradation by NnlA. Appl. Environ. Microbiol. 2022, 88, e0102322. DOI: 10.1128/aem.01023-22

22. Ma, Z; Holland, A.A.; Szlamkowicz, I.; Anagnostopoulos, V.A.; Caldas Nogueira, M.L.; Caranto, J.D.; Davidson, V.L. The hemerythrin-like diiron protein from Mycobacterium kansasii is a nitric oxide peroxidase. J. Biol. Chem. 2022, 298, 101696. DOI: 10.1016/j.jbc.2022.101696
Table of contents graphic for 2021 Biochemistry paper by Chris Martin

21. Martin, C.P.; Chen, M.; Martinez, M.F.; Ding, Y.; Caranto, J.D. The ferric-superoxo intermediate of the TxtE nitration pathway resists reduction, facilitating its reaction with nitric oxide. Biochemistry 2021, 60, 2436–2446. DOI: 10.1021/acs.biochem.1c00416

20. Caranto, J.D. The emergence of nitric oxide in the biosynthesis of bacterial natural products, Curr. Opin. Chem. Biol. 2019, 49, 130–138. DOI: 10.1016/j.cbpa.2018.11.007

Pre-independent career publications by the PI

The PI’s prior published work was performed in the labs of Dr. Jonathan King (Trinity University), Dr. Donald Kurtz (University of Texas at San Antonio) and Dr. Kyle Lancaster (Cornell University). Most of these works focused on metalloenzyme systems related to the nitrogen cycle, environmental impacts of fertilization, and bacterial nitrosative stress protections. A list of these works are listed below:

19. Transue, W.J.; Snyder, R.A.; Caranto, J.D.; Kurtz, Jr., D.M.; Solomon, E.I. Particle Swarm Fitting of Spin Hamiltonians: Magnetic Circular Dichroism of Reduced and NO-Bound Flavodiiron Protein, Inorg. Chem. 2022, 61, 1247-1250.

18. Dong, M.; Kathiresan, V.; Fenwich, M.K.; Torelli, A.T.; Zhang, Y.; Caranto, J.D.; Dzikovski, B.; Lancaster, K.M.; Freed, J.H.; Ealick, S.E.; Hoffmann, B.M.; Lin, H. Organometallic and radical intermediates reveal the reaction mechanism for the diphthamide biosynthetic radical SAM enzyme, Science 2018, 359, 16520–16527.

17. Lancaster, K.M.; Caranto, J.D.; Majer, S.H.; Smith, M.A. Alternative bioenergy: Updates to and challenges in nitrification metalloenzymology, Joule 2018, 2, 421-441.

16. Vilbert, A.C.; Caranto, J.D.; Lancaster, K.M. The lysine cross-link to heme P460 obviates NO-dependent histidine-dissociation from Nitrosomonas europaea cytochrome P460 {FeNO}7, Chem. Sci. 2018, 9, 368-379.

15. Weitz, A.C; Giri, N.; Caranto, J.D.; Kurtz, D.M., Jr.; Bominaar, E.L.; Hendrich, M.P. Spectroscopy and DFT calculations of a flavo-diiron enzyme implicate new diiron site structures, J. Am. Chem. Soc. 2017, 139, 12009–12019.

14. Caranto, J.D.; Lancaster, K.M. Nitric oxide is an obligate bacterial nitrification intermediate produced by hydroxylamine oxidoreductase, Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 8217–8222.

13. Caranto, J.D; Vilbert, A.C.; Lancaster, K.M. Nitrosomonas europaea cytochrome P460 is a direct link between nitrification and nitrous oxide emission, Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 14704–14709.

12. Frederick, R.E.; Caranto, J.D.; Masitas, C.A.; Gebhardt, L.L.; MacGowan, C.E.; Limberger, R.J.; Kurtz, D.M., Jr. Dioxygen and nitric oxide scavenging by Treponema denticola flavo-diiron protein: A mechanistic paradigm for catalysis, J. Biol. Inorg. Chem. 2015, 20, 603–613.

11. Caranto, J.D.; Weitz, A.; Giri, N.; Hendrich, M.P.; Kurtz, D.M., Jr. A diferrous-dinitrosyl intermediate in the N2O-generating pathway of a deflavinated flavo-diiron protein, Biochemistry 2014, 53, 5631–5637.

10. Caranto, J.D.; Weitz, A.; Hendrich, M.P.; Kurtz, D.M., Jr. The nitric oxide reductase mechanism of flavo-diiron protein: Identification of active-site intermediates and products, J. Am. Chem. Soc. 2014, 136, 7981–7992.

9. Meininger, D.J.; Caranto, J.D.; Arman, H.D.; Tonzetich, Z.J. Studies of Iron(III) Porphyrinates Containing Silanethiolate Ligands, Inorg. Chem. 2013, 52, 12468–12476.

8. Kurtz, D.M., Jr.; Boice, E.; Caranto, J.D.; Frederick, R.E.; Masitas, C.A.; Miner, K.D. Iron: Non-heme protein with diiron-carboxylate active sites. In Encyclopedia of Inorganic and Bioinorganic Chemistry; Scott, R.A., Ed.; Wiley: New York, 2013.

7. Fang, H.; Caranto, J.D.; Mendoza, R.; Taylor A.B.; Hart, P.J.; Kurtz, D.M., Jr. Histidine ligand variants of a flavo-diiron protein: effects on structure and activities, J. Biol. Inorg. Chem. 2012, 17, 1231–1239.

6. Caranto, J.D.; Gebhardt, L.L.; MacGowan, C.E.; Limberger, R.J.; Kurtz, D.M., Jr. Treponema denticola superoxide reductase: In vivo role, in vitro reactivities and a novel [Fe(Cys)4] site, Biochemistry 2012, 51, 5601–5610.

5. Hayashi, T.; Caranto, J.D.; Matsumara, H.; Kurtz, D.M., Jr.; Moënne-Loccoz, P. Vibrational analysis of mononitrosyl complexes in hemerythrin and flavodiiron proteins: relevance to detoxifying NO reductase, J. Am. Chem. Soc. 2012, 134, 6878–6884.

4. Felhofer, J.L.; Caranto J.D.; Garcia C.D. Adsorption kinetics of catalase to thin-films of carbon nanotubes, Langmuir 2010, 26, 17178–17183.

3. Hayashi, T.; Caranto, J.D.; Wampler, D.A.; Kurtz, D.M., Jr.; Moënne-Loccoz, P. Insights into the nitric oxide reductase mechanism of flavo-diiron proteins from flavin-free enzyme, Biochemistry 2010, 49, 7040–7049.

2. Hillmann, F.; Riebe O.; Fischer R.; Mot A.; Caranto J.D.; Kurtz D.M., Jr.; Bahl, H. Reductive dioxygen scavenging by flavo-diiron proteins of Clostridium acetobutylicum, FEBS Lett. 2009, 583, 241–245.

1. Leone, A.K.; Chun, J.A.; Koehler, C.L.; Caranto, J.D.; King, J.K. Effect of proinflammatory cytokines tumor necrosis factor-α and interferon-γ on epithelial barrier function and matrix metalloproteinase-9 in Madin-Darby canine kidney cells, Cell. Physiol. Biochem. 2007, 19, 99–112.