Selected Journal Articles

Jin, K., Sam, I.H., Po, H.L., Lin, D., Ghazvini Zadeh, E.H., Chen, S*, Yuan, Y.*, Li, X.* Total Synthesis of Teixobactin. Nat. Commun., 2016, 7:12394 doi: 10.1038/ ncomms12394. Link

Publication 8 graphic

Logan, M.W.; Yuen, A.L.; Zheng, Y.; Hall, E.A. Hettinger, M.A.; Marks, R.M.; Hosler, M.L.; Rossi, F.M.; Yuan, Y.*; Uribe-Romo, F.* Heterogeneous Photoredox Synthesis of N-hydroxy-oxazolidinones Catalyzed by Metal-Organic Frameworks. Catal. Sci. Technol., 2016, 5647-5655. Link

Zheng, Y.; Zadeh, E.H.G.; Yuan, Y.* One-Pot, Enantioselective Synthesis of 2,3-Dihydroazulen-6(1H)-one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes. ‎Eur. J. Org. Chem20162115-2119. Link

Craig, W.; Chen, J. Richardson, D.; Thorpe, R., Yuan, Y.* A Highly Stereoselective and Scalable Synthesis of L-allo-Enduracididine. Org. Lett.,2015, 17, 4620-4623. Link

Zheng, Y.; Cleaveland, J.; Richardson, D.; Yuan, Y.* An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure−Activity Relationship (SAR) Study at C2 Position. Org. Lett., 2015, 17, 4240-4243. Link

Book Chapter

1. Yuan, Y.*; Wang, W. Post-Synthetic Chemical Modification of Oligonucleotides. Volume 9, Comprehensive Organic Synthesis, Ed. 2, 463-493, 2014. Link.

Prior to UCF

Journal Articles

24. Zewge, D.; Gosselin, F.; Tellers, D.M.; Davies, I.W.; Jadhav, V.; Nerurkar, S.S.; Yuan, Y.; Li, J.; Flanagan, W.M., Kenski, D.M. High-Throughput Chemical Modification of Oligonucleotides for Systematic Structure-Activity Relationship Evaluation. Bioconjugate Chem., 2014, 25, 2222.

23. Janout, V.; Cline, L.L.; Feuston, B.P.; Klein, L.; O’Brien, A.; Tucker, T.; Yuan, Y.; O’Neill-Davis, L.A.; Peiffer, R.L.; Nerurkar, S.S.; Jadhav, V.; Tellers, D.M., Regen, S.L. Molecular Umbrella Conjugate for the Ocular Delivery of siRNA. Bioconjugate Chem., 2014, 25, 197.

22. Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X., Danishefsky, S.J. Encouraging Progress in the omega-Aspartylation of Complex Oligosaccharides as a General Route to beta-N-Linked Glycopolypeptides. J. Am. Chem. Soc., 2011, 133, 1597.

21. Aaronson, J.G.; Klein, L.J.; Momose, A.A.; O’Brien, A.M.; Shaw, A.W.; Tucker, T.J.; Yuan, Y., Tellers, D.M. Rapid HATU-Mediated Solution Phase siRNA Conjugation. Bioconjugate Chem., 2011, 22, 1723.

20. Yuan, Y.; Chen, J.; Wan, Q.; Wilson, R.M., Danishefsky, S.J. Toward Fully Synthetic, Homogeneous Glycoproteins: Advances in Chemical Ligation. Biopolymers, 2010, 94, 373.

19. Joo, J.M.; David, R.A.; Yuan, Y., Lee, C. Concise Synthesis of the Erythrina Alkaloid 3-Demethoxyerythratidinone via Combined Rhodium Catalysis. Org. Lett., 2010, 12, 5704.

18. Yuan, Y.; Zhu, J.; Li, X.; Wu, X., Danishefsky, S.J. Preparation and reactions of Nthioformyl peptides from amino thioacids and isonitriles. Tetrahedron Lett., 2009, 50, 2329.

17. Yuan, Y.; Chen, J.; Wan, Q.; Tan, Z.; Chen, G.; Kan, C., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys(29)-Gly(77) Glycopeptide Domain. J. Am. Chem. Soc., 2009, 131, 5432.

16. Wu, X.; Yuan, Y.; Li, X., Danishefsky, S.J. Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry. Tetrahedron Lett., 2009, 50, 4666.

15. Wang, P.; Zhu, J.; Yuan, Y., Danishefsky, S.J. Total Synthesis of the 2,6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc., 2009, 131, 16669.

14. Tan, Z.; Shang, S.; Halkina, T.; Yuan, Y., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Non-NCL-Based Chemical Synthesis of the Gln(78)-Arg(166) Glycopeptide Domain. J. Am. Chem. Soc., 2009, 131, 5424.

13. Kan, C.; Trzupek, J.D.; Wu, B.; Chen, G.; Tan, Z.; Yuan, Y., Danishefsky, S.J. Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala(1)-Gly(28) Glycopeptide Domain by “Alanine” Ligation. J. Am. Chem. Soc., 2009, 131, 5438.

12. Wan, Q.; Chen, J.; Yuan, Y., Danishefsky, S.J. Oxo-ester Mediated Native Chemical Ligation: Concept and Applications. J. Am. Chem. Soc., 2008, 130, 15814.

11. Li, X.; Yuan, Y.; Kan, C., Danishefsky, S.J. Addressing Mechanistic Issues in the Coupling of Isonitriles and Carboxylic Acids: Potential Routes to Peptidic Constructs. J. Am. Chem. Soc., 2008, 130, 13225.

10. Li, X.; Yuan, Y.; Berkowitz, W.F.; Todaro, L.J., Danishefsky, S.J. On the TwoComponent Microwave-Mediated Reaction of Isonitriles with Carboxylic Acids: Regarding Alleged Formimidate Carboxylate Mixed Anhydrides. J. Am. Chem. Soc., 2008, 130, 13222.

9. Chen, J.; Wan, Q.; Yuan, Y.; Zhu, J., Danishefsky, S.J. Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis. Angew. Chem., Int. Ed., 2008, 47, 8521.

8. Yuan, Y.; Lai, A.J.; Kraml, C.M., Lee, C. A highly Enantio- and Diastereoselective 1,3-Dimethylallylation of Aldehydes. Tetrahedron, 2006, 62, 11391.

7. Joo, J.M.; Yuan, Y., Lee, C. Tandem Cyclization of Alkynes via Rhodium Alkynyl and Alkenylidene Catalysis. J. Am. Chem. Soc., 2006, 128, 14818.

6. Yuan, Y.; Men, H.B., Lee, C.B. Total Synthesis of Kendomycin: A Macro-CGlycosidation Approach. J. Am. Chem. Soc., 2004, 126, 14720.

Patents

5. Danishefsky, S. J.; David, J. D.; Chen, J.; Wu, B.; Chen, G.; Wan, Q.; Tan, Z.; Kan, C.; Yuan, Y.; Hua, Z.; Ranganathan, K.; Trzupek, J. D. Preparation of Homogeneous Erythropoietin and Other Peptides and Proteins. WO 2007/120614 A2 20071025

4. Aaronson, J.G.; Barnett, S.F.; Bartz, R.; Colletti, S.L.; Jadhav, V.R.; Momose, A.A.; Shaw, A.W.; Tellers, D.M.; Tucker, T.J.; Wang, W.; Yuan, Y. Novel Single Chemical Entities and Methods for Delivery of Oligonucleotides. WO 2011/126974

3. Colletti, S.L.; Gosselin, F.; Jadhav, V.R.; Shaw, A.W.; Tellers, D.M.; Tucker, T.J.; Yuan, Y.; Zewge, D. Novel Single Chemical Entities and Methods for Delivery of Oligonucleotides. WO 2012/030683

2. Tellers, D. M.; Colletti, S. L.; Dudkin, V.; Aaronson, J.; Momose, A.; Tucker, T. J.; Yuan, Y.; Calati, K. B.; Tian, L.; Parmar, R. G.; Shaw, A. W.; Wang, W.; Storr, R. A.; Busuek, M.; Kowtoniuk, R. A. Novel TetraGalNAc and Peptide Containing Conjugates and Methods for Delivery of Oligonucleotides. WO 2013166155

1. Tellers, D. M.; Colletti, S. L.; Dudkin, V.; Ikemoto, N.; Liao, H.; Parish, C.; Pei, T.; Shaw, A. W.; Truong, Q.; Wang, L.; Yuan, Y.; Zhu, M. Novel TetraGalNAc Containing Conjugates and Methods for Delivery of Oligonucleotides. WO 2013166121