Abstract: Human trafficking (labor, sex, domestic servitude and organ harvesting) has been framed in primarily moral and criminal justice terms until recently. Using the legal definitions of human trafficking as our operational/case definition, we will explore how the application of an applied science model (alternatively, a public health approach), can assist us to achieve multiple desired outcomes. First among these is effective treatment for survivors of trafficking. This also involves generating accurate estimates of the scope of the trafficking problem. Another important outcome is the prevention of trafficking perpetration and victimization. Effective treatment for those who perpetrate human trafficking is a desired outcome. We will discuss multiple models that address these outcomes and the utilization of scientific knowledge that can be applied to addressing the “wicked problem” of human trafficking.