In our laboratory, we developed a new gold nanoparticle probe-based single-step, label-free, and washing-free biomolecular assay platform. Target molecules and species including proteins, DNAs, and infectious pathogens such as viruses and bacteria are detected by monitoring the gold nanoparticle aggregate formation using dynamic light scattering. We are currently using this assay platform to develop new diagnostic and screening tests for infectious diseases and early cancer detection. Our research aims to reveal both fundamental understanding and practical applications that will benefit both human and animal health management and infectious disease control.
- Huo, Q.; Litherland, S.A.; Sullivan, S.; Hallquist, H.; Decker, D.A.; Rivera-Ramirez, I. Developing a nanoparticle test for prostate cancer scoring. J. Translational Medicine, 2012, published online.
- Jans, H.; Huo, Q. Gold nanoparticle-enabled biological and chemical detection and analysis. Chem. Soc. Rev. 2011, published online (DOI: 10.1039/C1CS15280G).
- Huo, Q.; Cordero, A.; Bogdanovic, J.; Colon, J.; Baker, C.H.; Goodison, S.; Pensky, M. A facile nanoparticle immunoassay for cancer biomarker discovery. J. Nanobiotechnology, 2011, 9:20 (Open Access).
- Jaganathan, S.; Yue, P.; Paladino, D.C.; Bogdanovic, J.; Huo, Q.; Turkson, J. A functional nuclear epidermal growth factor receptor, Src and Stat3 heteromeric complex in pancreatic cancer cells. PLoS One, 2011, 6(5):e19605 (Open Access). 6
- Chen, H.; Chunder, A.; Liu, X.; Haque, F.; Zou, J.; Austin, L.; Knowles, G.; Zhai, L.; Huo, Q. A multifunctional gold nanoparticle/polyelectrolyte fibrous nanocomposite prepared from electrospinning process. Materials Express 2011, 1, 154-159.
- Li, S.; Li, J.; Wang, K.; Wang, C.; Xu, J.; Chen, H.; Xia, X.; Huo, Q. A nanochannel array-based electrochemical device for quantitative label-free DNA analysis. ACS Nano 2010, 4, 6417-6424.
- Jans, H.; Jans, K.; Lagae, L.; Borghs, G.; Maes, G.; Huo, Q. Poly(acrylic acid)-stabilized colloidal gold nanoparticles: synthesis and properties. Nanotechnology 2010, 21, 455702-455708.
- Bogdanovic, J.; Colon, J.; Baker, C.; Huo, Q. A label-free nanoparticle aggregation assay for protein complex/aggregate detection and analysis. Anal. Biochem. 2010, 405, 96-102.
- Huo, Q. Protein complexes/aggregates as potential cancer biomarker revealed by a nanoparticle aggregation immunoassay. Colloids Surf. B. 2010, 78, 259-265.
- Bogdanovic, J.; Huo, Q. NanoDLSay: a new platform technology for biomolecular detection and analysis using gold nanoparticle probes coupled with dynamic light scattering. SPIE Proceeding
Our group is strongly oriented towards multidisciplinary research that involves the chemical synthesis, property studies, and theoretical modeling of nanomaterials. Our research team consists of chemists, physicists, material engineer, and mathematician. Graduate and undergraduate students working on this project will learn the general as well as more advanced research tools to develop and study nanomaterials. Students trained in this program will grasp a much enhanced understanding on the significance of nanomaterials in future science and technology development.