Publications

Smith, Layton H; Pinkerton, Anthony B; Hershberger, Paul M; Maloney, Patrick R; McAnally, Danielle. Apelin Receptor Agonists and Methods of use Thereof. US11673873.

Berneburg, Isabell; Peddibhotla, Satyamaheshwar; Heimsch, Kim C; Haeussler, Kristina; Maloney, Patrick; Gosalia, Palak; Preuss, Janina; Rahbari, Mahsa; Skorokhod, Oleksii; Valente, Elena; et. al. An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase. Antimicrobial Agents and Chemotherapy (2022), 66(64), 1-16.

Dobrovolskaite, Aiste; Moots, Holly; Tantank, Mukund P; Shah, Kunal; Thomas, Jenna; Dinara, Sharifa; Massaro, Chelsea; Hershberger, Paul M; Maloney, Patrick R; Peddibhotla, Satyamaheshwar; et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents that Inhibit Far Upstream Element Binding Protein-1 (FUBP1) Function. J. Med. Chem. (2022), 65(22), 15391-15415.

Sangaralingham, Jeson; Whig, Kanupriya; Peddibhotla, Satyamaheshwar; Kirby, Jason R; Sessions, Hampton E; Maloney, Patrick R; Hershberger, Paul M; Mose-Yates, Heather; Hood, Becky L; Vasile, Stefan; et al. Discovery of Small Molecule Guanylyl Cyclase-A Receptor Positive Allosteric Modulators. Proc. Nat. Acad. Sci. USA. (2021), 118(52), e2109256118.

Burnett, John C; Sangralingham, Jeson; Malany, Siobhan; Sessions, Edward Hampton Jr; Peddibhotla, Satyamaheshwar; Hershberger, Paul Mitchell; Maloney, Patrick Reed. Synthesis of Heterocyclic Particulate Guanylyl Cyclase Receptor-A Enhancers Treating Cardiovascular, Renal, and Metabolic Diseases and Cancers. WO2021243230.

Pinkerton, Anthony B; Sessions, Hampton E; Hershberger, Paul M; Maloney, Patrick R; Peddibhotla, Satyamaheshwar; Hopf, Meghan; Sergienko, Eduard; Ma, Chen-Ting; Smith, Layton H; Jackson, Michael R; et al. Optimization of Urea-containing Series of Nictinamide Phosphoribosyltransferase (NAMPT) Activators. Bioorg & Med Chem Lett. (2021), 41, 128007.

Peddibhotla, Satyamaheshwar; Hershberger, Paul M; Kirby, Jason R; Malany, Siobhan; Smith Layton H; Maloney, Patrick R; Sessions, Hampton E; Divlianksa, Daniela; Pinkerton, Anthony B. Preparation of Azabicyclononanes and Diazabicyclononaes as CXCR6 Inhibitors and Methods of use. WO2021007208.

Peddibhotla, Satyamaheshwar; Hershberger, Paul M; Kirby, Jason R; Sugarman, Elliot; Maloney, Patrick R; Sessions, Hampton E; Divlianska, Daniela; Morfa, Camilo; Terry, David; Pinkerton, Anthony B; et al. Discovery of Small Molecule Antagonists of Chemokine Receptor CXCR6 that Arrest Tumor Growth in SK-HEP-1 Mouse Xenografts as a Model of Hepatocellular Carcinoma. Bioorg & Med Chem Lett. (2020), 30(4), 126889.

Phanstiel, Otto IV; Moots, Holly; Maloney, Patrick; Hershberger, Paul; Peddibhotla, Satyamaheshwar. Preparation of Piperazinylphenyl Benzamide Dderivatives as Non-polyamine Based Polyamine Transport Inhibitors and their use in the Treatment of Human Cancers. WO2020033944.

Slosky, Lauren M; Bai, Yushi; Ray, Caroline; Rochelle, Lauren K; Chandrasekhar, Rahul; Atluri, Namratha; Toth, Krisztian; Badea, Alexandra; Pogorelov, Vladimir M; Abraham, Dennis M; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick; Yuan, Hong; Li, Zibo; Wetsel, William C; Pinkerton, Anthony B; Barak, Lawrence S; Caron, Marc G. B-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell 2020, 181(6) 1364-1379.

Smith, Layton H; Maloney, Patrick; McAnally, Danielle; Hershberger, Paul; Sessions, Hampton; Peddibhotla, Satyamaheshwar. 4-Aminoquinoline Compounds for the Treatment of Pathological Angiogenesis. WO2019173482.

Pinkerton, Anthony B; Peddibhotla, Satyamaheshwar; Yamamoto, Fusayo; Maloney, Paatrick; Hershberger, Paul; Hedrick, Michael; Falter, Bekhi; Ardecky, Robert; Smith, Layton H; Chung, Thomas D.Y.; Jackson, Michael R; Slosky, Lauren M; Bai, Yushi; Caron, Marc; Barak, Lawrence S. Discovery of B-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J. Med. Chem. 2019, 62(17), 8357-8363.

Smith, Layton H.; Pinkerton, Anthony B.; Hershberger, Paul; Maloney, Patrick; McAnally, Danielle. Preparation of Pyrazolopyrimidines as Apelin Receptor Agonists and Methods of use Thereof. WO2019032720.

McAnally, Danielle; Siddiquee, Khandakar; Gomaa, Ahmed; Szabo, Andras; Vasile, Stefan; Maloney, Patrick r.; Divlianska, Daniela B.; eddibhotla, Satyamaheshwar; Morfa, Camilo J.; Hershberger, Paul; Falter, Rebecca; Williamson, Robert; Terry, David B.; Farjo, Rafal; Pinkerton, Anthony B.; Qi, Xiaping; Quigley, Judith; Bolton, Michael E.; Grant, Maria B.;Smith, Layton H. Repurposing Antimalarial Aminoquinolines and Related Compounds for Treatment of Retinal Neovascularization. PloS One (2018) 13(9), e0202436/1 – e0202436/23.

Jason Kirby, Daniela B. Divlianska, Kanupriya Whig, Nadezda Bryan, Camilo J. Morfa, Ada Koo, Becky L. Hood, Kevin H. Nguyen, Patrick Maloney, Satyamaheshwar Peddibhotla, E. Hampton Sessions, Paul M. Hershberger, Layton H. Smith, Siobhan Malany. Discovery of Novel Small Molecule Inducers of Heme Oxygenase-1 that Protect iPSC-derived Cardiomyocytes from Oxidative Stress. J. Pharm. Exp. Ther. January 2018, 364(1) 87-96.

Price, Daniel J.; Drewry, David H.; Shaller, Lee T.; Thompson, Brian D.; Reid, Paul R.; Maloney, Patrick R.; Liang, Xi; Banker, Periette; Buckholz, Richard G.; Selley, Paula K.; McDonald, Octerloney B.; Smith, Jeffrey L.; Shearer, Todd W.; Cox, Richard F.; Williams, Shawn P.; Reid, Robert A.; Tacconi, Stefano; Faggioni, Federico; Wang, Tony Y. An Orally Available, Brain Penetrant CAMKK2 Inhibitor Reduces Food Intake in Rodent Model. Bioorg. Med. Chem. Lett. (2018) 28(10), 1958-1963.

Smith, Layton H.; Pinkerton, Anthony B.; Hershberger, Paul M.; Maloney, Patrick R.; McAnally, Danielle. Apelin Receptor Agonists and Methods of use Thereof. WO2016176473.

Larry S. Barak, Yushi Bai, Sean Peterson, Tama Evron, Nikhil Urs, Satyamaheshwar Peddibhotla, Michael P Hedrick, Paul Hershberger, Patrick R. Maloney, Thomas D.Y. Chung, Ramona M. Rodriguiz, William C. Wetsel, James B. Thomas, Glen R. Hanson, Anthony B Pinkerton, and Marc G. Caron. ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem. Biol. (2016) 11(5), tbd.

Pinkerton, Anthony, B.; Hershberger, Paul, M.; Peddibhotla, Satyamaheshwar; Maloney, Patrick, R.; Hedrick, Michael, P. Preparation of substituted quinazolines as small molecule agonists of neurotensin receptor 1. WO2015200534.

Satyamaheshwar Peddibhotla, Pauline Fontaine, Chi K. Leung, Patrick Maloney, Paul M Hershberger, Ying Wang, Michelle S Bousquet, Hendrik Luesch, Arianna Mangravita-Novo, Anthony B Pinkerton, Layton H. Smith, Siobhan Malany, and Keith Choe. Discovery of ML358, a selective small molecule inhibitor of the SKN-1 pathway involved in drug detoxification and resistance in nematodes. ACS Chem. Biol. (2015) 10(8), 1871-1879.

Pinkerton, Anthony; Maloney, Patrick; Hershberger, Paul; Peddibhotla, Satyamaheshwar; Hedrick, Michael; Barak, Lawrence; Caron, Marc. Preparation of piperazinylquinazolines and related compounds as agonists of neurotensin receptor 1. WO2014100501.

Sparks, Steven M.; Chen, Grace; Collins, Jon L.; Danger, Dana; Dock, Steven T.; Jayawickreme, Channa; Jenkinson, Stephen; Laudeman, Christopher; Leesnitzer, M. Anthony; Liang, Xi; Maloney, Patrick; McCoy, David c.; Moncol, David; Rash, Vincent; Rimele, Thonas; Vulimiri, Padmaja; Way, James M.; Ross, Sean. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg. Med. Chem. Lett. (2014) 24, 3100-3103.

Paul M. Hershberger, Eliot Sugarman, Patrick Maloney, Satyamaheshwar Peddibhotla, Ada Koo, Eigo Suyama, Manuel E. Ruidiaz, Susanne Heynen-Genel, Kevin H. Nguyen, Stefan Vasile, Arianna Mangravita-Novo, Layton H. Smith, Mangala M. Soundarapandian, Sumeet Salaniwal, Paul Kung, Rick B. Vega, Thomas D.Y. Chung, Anthony B. Pinkerton, Siobhan Malany, and Daniel P. Kelly.  Inhibitors of Myocyte Triacylglyceride Accumulation. Probe Reports from the NIH Molecular Libraries Program. 2013.

Satyamaheshwar Peddibhotla, Chi K. Leung, Patrick Maloney, Paul M. Hershberger, Kevin Nguyen, Stefan Vasile, Eigo Suyama, Ada Kane, Michelle S. Bousquet, Hendrick Leusch, Derek Stonich, Arianna Mangravita-Novo, Sumeet Salaniwal, Paul Kung, Jena Diwan, Layton H. Smith, Thomas D.Y. Chung, Anthony B. Pinkerton, Siobhan Malany, and Keith Choe. A High Throughput Screen for Inhibitors of Nematode Detoxification Genes. Probe Reports from the NIH Molecular Libraries Program. 2013.

Peddibhotla, Satyamaheshwar; Hedrick, Michael P.; Hershberger, Paul; Maloney, Patrick R.; Li, Yujie; Milewski, Monika; Gosalia, Palak; Gray, Wilson; Mehta, Alka; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Heynen-Genel, Susanne; Vasile, Stefan; Saliniwal, Sumeet; Stonich, Derek; Su, Ying; Mangravita-Novo, Arianna; Vicchiarrelli, Michael; Roth, Gregory P.; Smith, Layton H.; Chung, Thomas D. Y.; Hanson, Glen R.; Thomas, James B.; Caron, Marc G.; Barak, Lawrence S.; Pinkerton, Anthony B. Discovery of ML314, a Brain Penetrant Nonpeptidic b-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med. Chem. Lett. (2013), 4(9), 846-851.

Paul M. Hershberger, Satyamaheshwar Peddibhotla, Eliot Sugarman, Patrick Maloney, Danielle Key, Eigo Suyama, Kevin Nguyen, Stefan Vasile, Martha Kraft, Derek Stonich, Arianna Mangravita-Novo, Michael Vicchiarelli, Palak Gosalia, Monica Milewski, Linda Li, Michael Hedrick, Qing Sun, Eduard Sergienko, Anton Cheltsov, Sumeet Salanawil, Jena Diwan, Layton H. Smith, Russell S. Taichman, Thomas D.Y. Chung, Anthony B. Pinkerton, Siobhan Malany, and Gregory P. Roth. Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis. Probe Reports from the NIH Molecular Libraries Program. 2012.

Ada Kane, Satyamaheshwar Peddibhotla, Patrick Maloney, Alka Mehta, Becky Hood, Eigo Suyama, Kevin Nguyen, Stefan Vasile, Laurel Leavitt, Anton Cheltsov, Sumeet Salaiwal, Derek Stonich, Arianna Mangravita-Novo, Michael Vicchiarelli, Layton H. Smith, Jena Diwan, Thomas D.Y. Chung, Anthony B. Pinkerton, Paul Hershberger, Siobhan Malany, and Richard N. Kitsis. Cardioprotective Inhibitors of Reperfusion Injury. Probe Reports from the NIH Molecular Libraries Program. 2012.

Paul Hershberger, Michael Hedrick, Satyamaheshwar Peddibhotla, Patrick Maloney, Yujie Li, Monika Milewski, Palak Gosalia, Wilson Gray, Alka Mehta, Eliot Sugarman, Becky Hood, Eigo Suyama, Kevin Nguyen, Susanne Heynen-Genel, Stefan Vasile, Sumeet Salaniwal, Derek Stonich, Ying Su, Arianna Mangravita-Novo, Michael Vicchiarelli, Layton H. Smith, Gregory Roth, Jena Diwan, Thomas D.Y. Chung, Marc G. Caron, James B. Thomas, Anthony B. Pinkerton, and Lawrence R. Barak. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists). Probe Reports from the NIH Molecular Libraries Program. 2012.

Patrick Maloney, Michael Hedrick, Satyamaheshwar Peddibhotla, Paul Hershberger, Monika Milewski, Palak Gosalia, Linda Li, Janina Preuss, Eliot Sugarman, Becky Hood, Eigo Suyama, Kevin Nguyen, Stefan Vasile, Eduard Sergienko, Sumeet Salanawil, Derek Stonich, Ying Su, Russell Dahl, Arianna Mangravita-Novo, Michael Vicchiarelli, Danielle McAnally, Layton H. Smith, Gregory Roth, Jena Diwan, Thomas D.Y. Chung, Anthony B. Pinkerton, Lars Bode, and Katja Becker. A 2^nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH)- Probe 2. Probe Reports from the NIH Molecular Libraries Program. 2012.

Maloney, Patrick R.; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; li, Linda; Roth, Gregory P.; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, Fu-Yue; Mangravita-Novo, Arianna; Vicchiarrelli, Michael; Diwan, Jena; Chung, Thomas D. Y.; Smith, Layton H.; Pinkerton, Anthony B.  Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a Functional Antagonist of the Apelin (APJ) Receptor. Bioorg. and Med. Chem. Lett. (2012), 22(21), 6656-6660.

Preuss, Janina; Maloney, Patrick; Peddibhotla, Satyamaheshwar; Hedrick, Michael P.; Hershberger, Paul; Gosalia, Palak; Milewski, monica; Yujie, Linda; Sugarman, Elliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Vasile, Stefan; Sergienko, Eduard; Mangravita-Novo, Adrianna; Vicchiarelli, Michael; McAnally, Danielle; Smith, Layton H.; Roth, Gregory P.; Diwan, Jena; Chung, Thomas D.Y.; Jortzik, Esther; Rahlfs, Stefan; Becker, Katja; Pinkerton, Anthony B.; Bode, Lars. Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6-phosphogluconolactonase Inhibitor (R,Z)-N-(( 1-Ethylpyrrolidin-2-yl)methyl)-2-(2-flurobenzylidine)-3-oxo-3,4-dihydro-2-H-benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro. J. Med. Chem. (2012) 55(16), 7262-7272.

Patrick Maloney, Michael Hedrick, Satyamaheshwar Peddibhotla, Paul Hershberger, Monika Milewski, Palak Gosalia, Linda Li, Janina Preuss, Eliot Sugarman, Becky Hood, Eigo Suyama, Kevin Nguyen, Stefan Vasile, Eduard Sergienko, Sumeet Salanawil, Derek Stonich, Ying Su, Russell Dahl, Arianna Mangravita-Novo, Michael Vicchiarelli, Danielle McAnally, Layton H. Smith, Gregory Roth, Jena Diwan, Thomas D.Y. Chung, Anthony B. Pinkerton, Lars Bode, and Katja Becker. A Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH). Probe Reports from the NIH Molecular Libraries Program. 2011.

Pasha Khan, Patrick R Maloney, Michael Hedrick, Palak Gosalia, Monika Milewski, Linda Li, Gregory P Roth, Eduard Sergienko, Eigo Suyama, Eliot Sugarman, Kevin Nguyen, Alka Mehta, Stefan Vasile, Ying Su, Shenghua Shi, Derek Stonich, Hung Nguyen, Fu-Yue Zeng, Arianna Mangravita Novo, Michael Vicchiarelli, Jena Diwan, Thomas DY Chung, Anthony B Pinkerton, and Layton H Smith. Functional Agonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program. 2011.

Patrick R. Maloney, Pasha Khan, Michael Hedrick, Palak Gosalia, Monika Milewski, Linda Li, Gregory P. Roth, Eduard Sergienko, Eigo Suyama, Eliot Sugarman, Kevin Nguyen, Alka Mehta, Stefan Vasile, Ying Su, Derek Stonich, Hung Nguyen, Fu-Yue Zeng, Arianna Mangravita Novo, Michael Vicchiarelli, Jena Diwan, Thomas D.Y. Chung, Anthony B. Pinkerton, and Layton H. Smith. Functional Antagonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program. 2011.

Dmitri Rozanov, Brock Brown, Cheng-Tien Hung, Eduard Sergienko, Carlton Gasior, Palak Shah, Steve Vasile, Ying Su, Derek Stonich, Patrick Maloney, Greg Roth, Shakeela Dad, and Thomas DY Chung. uHTS for the Identification of Compounds that Potentiate TRAIL-induced Apoptosis of Cancer Cells. Probe Reports from the NIH Molecular Libraries Program. 2009.

Whitby, Richard J.; Dixon, Sally; Maloney, Patrick R.; Delerive, Philippe; Goodwin, Bryan J.; Parks, Derek J.; Willson, Timothy M. Identification of Small Molecule Agonists of the Orphan Nuclear Receptors Liver Receptor Homolog-1 and Steroidogenic Factor-1. J. Med. Chem. (2006) 49(23), 6652-5.

Boggs, Sharon D.; Collins, Jon L.; Hyatt, Stephen M.; Maloney, Patrick R. Preparation of Isoxazole Derivatives as Farnesoid X-Receptor Agonists. WO2004048349.

Pellicciari Roberto; Fiorucci Stefano; Camaioni Emidio; Clerici Carlo; Costantino Gabriele; Maloney Patrick R; Morelli Antonio; Parks Derek J; Willson Timothy M.  6-alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity.    J. Med. Chem.  2002  45(17),  3569-72.

Goodwin, Bryan James; Jones, Stacey Ann; Kliewer, Steven Anthony; Maloney, Patrick Reed. Identification of New Therapeutic Targets for Modulating Bile Acid Synthesis. WO200210769.

Goodwin, Bryan; Jones, Stacey A.; Price, Roger R.; Watson, Michael A.; McKee, David D.; Moore, Linda B.; Galardi, Cristin; Wilson, Joan G.; Lewis, Michael C.; Roth, Matthew E.; Maloney, Patrick R.; Willson, Timothy M.; Kliewer, Steven A.  A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis. Mol. Cell. 2000, 6, 517-26

Mayuko Nakahara, Hiroshi Fujii, Patrick R. Maloney, Makoto Shimizu, and Ryuichiro Sato. Bile Acids Enhance Low Density Lipoprotein Receptor Gene Expression via a MAP Kinase Cascade-mediated Stabilization of mRNA.  J. Biol. Chem. (2002) 277(40), 37229-34.

Maloney, Patrick R.; Haffner, Curt D.; Fivush, Adam M.; Plunket, Kelli; Creech, Katrina L.; Parks, Derek J.; Willson, Timothy M.  Identification of a Non-steroidal Ligand for the Nuclear Bile Acid Receptor FXR. Abstr. Pap. – Am. Chem. Soc.  (2000),  220th  MEDI-316.

Maloney, Patrick R.; Parks, Derek J.; Haffner, Curt D.; Fivush, Adam M.; Chandra, Gyan; Plunket, Kelli D.; Creech, Katrina L.; Moore, Linda B.; Wilson, Joan G.; Lewis, Michael C.; Jones, Stacey A.; Willson, Timothy M. Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR. J. Med. Chem 2000, 43(16), 2971-4.

McDonald, Octerloney; Lackey, Karen; Davis-Ward, Ronda; Wood, Edgar; Samano, Vicente; Maloney, Patrick; Deanda, Felix; Hunter, Robert. Aza-stilbenes as Potent and Selective c-RAF Inhibitors. Bioorg. & Med. Chem. Lett. (2006), 16(20), 5378-83.

Marcos Sznaidman, Curt D. Haffner, Patrick R. Maloney, Adam Fivush, Esther Chao, Donna Goreham, Michael L. Sierra, Christelle LeGrumelec, H. Eric Xu, Valerie Montana, Millard H. Lambert, Timothy M. Willson, William R. Oliver, Jr., Daniel D. Sternbach. Novel Selective Small Molecule Agonists for Peroxisome Proliferator-Activated Receptor d (PPAR d)-Synthesis and Biological Activity. Bioorg. & Med. Chem. Lett. 13 (2003) 1517-21.

Chao, Esther Yu-Hsuan; Haffner, Curt Dale; Lambert, Millard Hurst, III; Maloney, Patrick Reed; Sierra, Michael Lawrence; Sternbach, Daniel David; Sznaidman, Marcos Luis; Willson, Timothy Mark; Xu, Huaqiang Eric; Gellibert, Francoise Jeanne.  Preparation of Thiazoles and Oxazoles as Selective Activators of Human PPAR delta. WO2001000603

Collins, Jon Loren; Fivush, Adam M.; Maloney, Patrick Reed; Stewart, Eugene L.; Willson, Timothy Mark. Preparation of Substituted Phenylacetamides and Benzamides as Agonists for Liver X Receptors (LXR). WO200224632

Moss, Marcia; Becherer, J. David; Milla, Marcos; Pahel, Gregory; Lambert, Mill; Andrews, Rob; Frye, Stephen; Haffner, Curt; Cowan, David; Maloney, Patrick; Dixon, Eric P.; Jansen, Marilyn; Vitek, Michael P.; Mitchell, Justin; Leesnitzer, Tony; Warner, Janet; Conway, James; Bickett, D. Mark; Bird, Mike; Priest, Richard; Reinhard, John; Lin, Peiyuan.  TNFa converting enzyme.    Metalloproteinases as Targets for Anti-Inflammatory Drugs. 1999, 187-203. Birkhauser Verlag Basel, Switzerland

Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Hiner, Roger N.; Dorsey, George F.; Noe, Robert A.; Unwalla, Rayomand J.; Batchelor, Kenneth W.; Bramson, H. Neal; et al. Structure-Activity Relationships for Inhibition of Type I and II Human 5 a -Reductase and Human Adrenal 3 b -hydroxy-D 5-steroid Dehydrogenase/ 3-Keto- D 5-steroid Isomerase by 6-Azaandrost-4-en-3-ones: Optimization of the C-17 Substituent. J. Med. Chem. 1995, 38, 2621-7.

Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Mook, Robert A., Jr.; Dorsey, George F.; Hiner, Roger N.; Cribbs, Cindy M.; Wheeler, Thomas N.; Ray, John A.; et al. 6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5 a -Reductase and Human 3 b -hydroxy- D 5-steroid Dehydrogenase/ 3-Keto- D 5-steroid Isomerase, J. Med. Chem. 1994, 37,  2352-60.

Andrews, Robert Carl; Cribbs, Cynthia Markert; Frye, Stephen Vernon; Haffner, Curt Dale; Maloney, Patrick Reed. Preparation of substituted 6-azaandrostenones as 5a -testosterone reductase inhibitors. Substituted 6-Azaandrostenones. WO 94/14833.

Maloney, Patrick R.; Fang, Francis G. Synthesis of a B-homo-6-azaandrost-4-ene-3-one as a novel steroidal 5a-reductase inhibitor. Tet. Lett.  (1994),  35(18),  2823-6.

Synthesis of a B-Homo 6-Azaandrost-4-en-3-one as a Potent Steroidal 5a-Reductase Inhibitor. Poster presentation, 1994 National ACS Meeting San Diego, CA.

Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Mook, Robert A., Jr.; Dorsey, G. F., Jr.; Hiner, Roger N.; Batchelor, Kenneth W.; Bramson, H. Neal; Stuart, J. Darren; et al. 6-Azasteroids: Potent Dual Inhibitors of Human Type 1 and 2 Steroid 5 a -Reductase. J. Med. Chem. 1993, 36, 4313-5.

Frye, Stephen Vernon; Cribbs, Cynthia Markert; Haffner, Curt Dale; Maloney, Patrick Reed; Andrews, Robert Carl. Preparation of 17-acyl-6-azaandrost-4-en-3-ones as testosterone 5a-reductase inhibitors. WO 93/13124.

Howard, Harry R.; Lowe, John A. III; Seeger, Thomas F.; Seymour, Patricia A.; Zorn, Stevin H.; Maloney, Patrick R.; Ewing, Frank E.; Newman, Michael E.; Schmidt, Anne W.; et al. 3-Benzisothiazolylpiperazine Derivatives as Potential Atypical Antipsychotic Agents. J. Med. Chem. 1996, 39, 143-8.

John A. Lowe, III, Thomas F. Seeger, Arthur A. Nagel, Harry R. Howard, Patricia A. Seymour, James H. Heym, Frank E. Ewing, Michael E. Newman, Anne W. Schmidt, Jerome S. Furman, Lawrence A. Vincent, Patrick R. Maloney, Gwendolyn L. Robinson, Linda S. Reynolds, and Fredric J Vinick. 1-Naphthylpiperazine Derivatives as Potential Atypical Antipsychotic Agents, J. Med. Chem., 1991, 34, 1860-6.

Gupton, John T.; Miller, John F.; Bryant, Robert D.; Maloney, Patrick R.; Foster, Bruce S. The Preparation of Aromatic Amidino Esters and Their Reaction with Primary Amines. Tetrahedron  (1987), 43(8), 1747-52.