People » Dmitry Kolpashchikov


Visit our research website: http://sciences.ucf.edu/chemistry/dmk-biochemlab/

We develop DNA nanomachines for biomedical applications. Our DNA machines can recognize RNA molecules with high selectivity, unwind their secondary structures and either detect or cleave them. The DNA machines can be used as highly specific sensors for biological RNA. Alternatively, they can be used for suppression of cancer cells or RNA-containing viruses. We plan to use the machines for anti-viral and anti-cancer treatment.

Click here for complete list of publications

2018

  1. Bakshi S. F., Guz N., Zakharchenko A., Deng H., Tumanov A., Woodworth C. D., Minko S., Kolpashchikov D. M., Katz E. (2018) Nanoreactors Based on DNAzyme-Functionalized Magnetic Nanoparticles Activated by Magnetic Field. Nanoscale, 10, 1356–1365.

2017

  1. Fedotova T. A. Kolpashchikov D. M. (2017) Liquid-to-Gel Transition for Visual and Tactile Detection of Biological Analytes. Chem. Commun. (Camb.), 53, 12622 – 12625. This paper was featured on the front cover of the journal. In addition, this article was highlighted by Chemistry World, monthly chemistry news magazine published by the Royal Society of Chemistry https://www.chemistryworld.com/news/tactile-alternative-to-colour-changes/3008395.article
  2. Kamar O., Sun S. C., Lin C. H., Chung W. Y., Lee M. S., Liao Y. C., Kolpashchikov D. M., Chuang M. C. (2017) A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids. Chem. Commun. (Camb.), 53, 10592-10595.
  3. Bakshi S.F., Guz N., Zakharchenko A., Deng H., Tumanov A., Woodworth C. D., Minko S., Kolpashchikov D. M., Katz E. (2017) Magnetic Field-Activated Sensing of mRNA in Living Cells. Journal of the American Chemical Society, 139, 12117-12120.
  4. Smith A., Kolpashchikov D. M. (2017) Divide and Control: Comparison of Split and Switch Hybridization Sensor. ChemistrySelect, 2, 5427-5431.
  5. Kikuchi N., Kolpashchikov D. M. (2017) Universal Split Spinach Aptamer (USSA) Probe for Nucleic Acid Analysis and DNA/RNA Computation. Chem. Commun. (Camb.), 53, 4977-4980.
  6. Campbell E. A., Peterson E., Kolpashchikov D. M. (2017) Self-Assembling Molecular Logic Gates Based on DNA Crossover Tiles. ChemPhysChem, 18, 1730-1734.
  7. Bengtson H. N., Homolka S., Niemann S., Reis A. J., da Silva P. E. A, Gerasimova Y. V., Kolpashchikov D. M. Rohde K. H. (2017) Multiplex Detection of Extensively Drug Resistant Tuberculosis using Binary Deoxyribozyme Sensors. Biosensors & Bioelectronics, 94, 176-183
  8. Mills D. M. Calvo-Marzal P., Pinzon J. M., Armas S., Kolpashchikov D. M., Chumbimuni-Torres K.Y.* (2017) A Single Electrochemical Probe Used for Analysis of Multiple Nucleic Acid Sequences. Electroanalysis, 29, 873–879.
  9. Gamella M.,  Zakharchenko A., Guz N., Masi M., Minko S., Kolpashchikov D. M., Iken H., Poghossian A.,  Schöning, M. J. Katz E.* (2017) DNA Computing Systems Activated by Electrochemically-Triggered DNA Release from a Polymer-Brush-Modified Electrode Array. Electroanalysis, 29, 398–408.

Motivated, open-minded students are welcome in our lab. Students will be involved in all aspects of scientific research including literature search, experiment design, data collection and analysis, poster and oral presentations, publishing in scientific journals. Techniques that students will be exposed in our lab include gel electrophoresis, UV/vis and fluorescent spectroscopy, SELEX, bioorganic synthesis (including DNA synthesis), chromatography (including HPLC), photochemistry and others.

 

Teaching: Biochemistry I course (BCH4053)

The course is focused on chemical structure and functions of the four major classes of biological molecules in the following order: carbohydrates, nucleic acids, proteins and lipids. The course builds on students’ prior knowledge of physical and organic chemistry to understand architecture of biological molecules and how this architecture makes biomolecules functionally active. The complex molecular interplay is illustrated by protein-nucleic acid interactions, membrane transport and biological signaling. ‘Introduction to metabolism’ prepares students for Biochemistry II course.

Each student in the class receives an individual score by the end of semester. Students who collected the highest scores during previous terms are listed below.

Student Name
Score
Score (%)
Term
Total number of students in the class
Christopher Reilly
976
97.6%
Fall 2009
148
Nicole Mailloux
947
94.7%
Spring 2010
223
David Delapena
934
93.4%
Fall 2010
184
Patricia Prieto
980
98.0%
Spring 2010
240
Lauren Holliday
980
98.0%
Fall 2011
300

Congratulations, Fall 2017 Ph.D. Graduates

In a reception hosted by Dean Michael Johnson, Ph.D., the College of Sciences celebrated its new Ph.D. graduates in the Physical Sciences building. Thirteen students were recognized with family members and facu... Read more

Introducing 13 New Ph.D. Graduates

In a reception hosted by Dean Michael Johnson, Ph.D., the College of Sciences celebrated its new Ph.D. graduates in the Physical Sciences building. Thirteen students were recognized with family members and fac... Read more

COS Excellence in Academics

The UCF College of Graduate Studies recognized graduate students and faculty for excellence in research, teaching and mentoring at an awards ceremony during the 13th Annual Graduate Research Forum on April 5, 2... Read more

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