- Biosensing and Diagnostics
Sensitive, reliable, and low-cost diagnostics are urgently needed for diagnosing diseases and detecting pollution, especially in resource-limited settings. We are committed to addressing challenge issues of current diagnostic techniques by taking advantage of the unique properties of nanomaterials (e.g., plasmonic and catalytic activities). For example, we are engineering bimetallic nanostructures as artificial enzymes for colorimetric assays. In another example, we are developing point-of-care diagnostics with enhanced detection sensitivity and specificity by utilizing catalytic nanocrystals. Our ultimate goal is to solve key healthcare problems with our technological innovations.
- Design and Synthesis of Functional Nanomaterials
The properties and performance of nanomaterials have strong dependence on their size, shape, and chemical composition. By carefully manipulating the thermodynamic and/or kinetic parameters during a synthesis, we aim to design and synthesize colloidal nanocrystals with specific morphologies and compositions sought for a variety of fundamental studies and technologically important applications. By taking advantage of modern high-resolution electron microscopy, we are interested in monitoring nanocrystal growth and characterizing final products at the atomic level, and gaining deep insight into the structure-property relationship.
- Effective and Sustainable Usage of Nanomaterials
To effectively use functional nanomaterials in certain applications, we enhance their performance by modifying their surfaces with unique chemical ligands, biomolecules, shells, and secondary functional nanoparticles. We investigate the roles played by surface chemistry in determining the properties of nanocrystals and the fundamental crystal growth process during synthesis. We are also interested in developing strategies for recycling and re-using high cost materials to achieve a sustainable usage of precious materials.
- Gao, Z.; Ye, H.; Tang, D.; Tao, J.; Habibi, S.; Minerick, A.; Tang, D.; Xia, X.* Platinum decorated gold nanoparticles with dual functionalities for ultrasensitive colorimetric in vitro diagnostics. Nano Letters, 2017, 17, 5572–5579. (It was highlighted by the NSF Science 360 News as a top story on 9.14.2017)
- Ye, H.; Yang, K.; Tao, J.; Liu, Y.; Zhang, Q.; Habibi, S.; Nie, Z.; Xia, X.* An enzyme-free signal amplification technique for ultrasensitive colorimetric assay of disease biomarkers. ACS Nano, 2017, 11, 2052–2059.
- Ye, H.; Wang, Q.; Catalano, M.; Lu, N.; Vermeylen, J.; Kim, M. J.; Liu, Y.; Sun, Y.; Xia, X.* Ru nanoframes with an fcc structure and enhanced catalytic properties. Nano Letters, 2016, 16, 2812–2817. (It was highlighted by C&EN News in the issue of March 28, 2016 and U.S. DOE Office of Science on April 4, 2016)
- Xia, X.;* Zhang, J.; Lu, N.; Kim, M. J.; Ghale, K.; Xu, Y.; Mckenzie, E.; Liu, J.; Ye, H. Pd-Ir core-shell nanocubes: A type of highly efficient and versatile peroxidase mimic. ACS Nano, 2015, 9, 9994–10004. (Highlighted by U.S. DOE office of science and U.S. CDC in Sept. 2015)
- Xia, X.; Figueroa-Cosme, L.; Tao, J.; Peng, H.-C.; Niu, G.; Zhu, Y.; Xia, Y. Facile synthesis of iridium nanocrystals with well-controlled facets using seed-mediated growth. Journal of the American Chemical Society, 2014, 136, 10878–10881.
- Xia, X.; Xie, S.; Liu, M.; Peng, H.-C.; Lu, N.; Wang, J.; Kim, M. J.; Xia, Y. On the role of surface diffusion in determining the shape or morphology of noble-metal nanocrystals. Proceedings of the National Academy of Sciences USA (PNAS), 2013, 110, 6669– (Highlighted in C&EN News, April 15, 2013, and many other news media)
- Xia, X.; Choi, S. I.; Herron, J. A.; Lu, N.; Scaranto, J.; Peng, H.-C.; Wang, J.; Mavrikakis, M.; Kim, M. J.; Xia, Y. Facile synthesis of Pd right bipyramids and their use as seeds for overgrowth and as catalysts for formic acid oxidation. Journal of the American Chemical Society, 2013, 135, 15706–15709.
- Xia, X.; Wang, Y.; Ruditskiy, A.; Xia, Y. Galvanic replacement: A simple and versatile route to metal nanostructures with tunable and well-controlled. Advanced Materials, 2013, 25, 6313– (for the 25th anniversary issue of Advanced Materials)
- Xia, X.; Xia, Y. Symmetry breaking during seeded growth of nanocrystals. Nano Letters, 2012, 12, 6038–
- Xia, X.; Zeng, J.; Otejen, L. K.; Li, Q.; Xia, Y. Quantitative analysis of the role played by poly(vinylpyrrolidone) in seed-mediated growth of silver nanocrystals. Journal of the American Chemical Society, 2012, 134, 1793–
- “CAREER: Engineering bimetallic nanostructures as peroxidase mimics for diagnostic applications”, Funding agency: Chemistry Division, NSF (Award# 1834874); Duration: 01/2017-01/2022; Role: PI.
- “Collaborative research: An enzyme-free amplification technique for ultrasensitive ELISA of disease biomarkers”. Funding agency: CEBT Division, NSF (Award# 1804525); Duration: 09/2018-08/2021; Role: PI.
Awards & Honors:
2018 Emerging Investigator, Journal of Materials Chemistry B, Royal Society of Chemistry
2017 NSF CAREER Award, National Science Foundation (NSF)
2017 Research Excellence Fund Award, Michigan Technological University